Abstract HIV infection remains incurable as the virus persists within a latent reservoir of CD4+T cells.Novel approaches to enhance immune responses against HIV are essential for effective control and potential cure of the infection.In this study, we designed a novel tetravalent bispecific antibody (Bi-Ab32/16) to simultaneously target the gp120 vi
Role of Exercise in Pulmonary Hypertension: Evidence from Bench to Bedside
Background: Pulmonary hypertension (PH) is a debilitating condition characterized by elevated pulmonary arterial pressure and progressive vascular remodelling, leading to exercise intolerance.The progression of PAH is regulated at a cellular and molecular level which influences various physiological processes.Exercise plays an important role in imp
Local inflammation, dissemination and coalescence of lesions are key for the progression towards active tuberculosis: the bubble model
The evolution of a tuberculosis (TB) infection towards active disease is driven by a combination of factors mostly related to the host response.The equilibrium between control of the bacillary load and the pathology generated is crucial as regards preventing the growth and proliferation of TB lesions.In addition, some experimental evidence suggests
The Value of Blood T Cell Frequencies for Risk Prediction of Postoperative Complications in Pancreatic Cancer Surgery
Objective:.To quantify and characterize preoperative blood T cells in patients with pancreatic ductal adenocarcinoma (PDAC), who underwent tumor resection, CBD Capsule and to determine their relevance as biomarkers for postoperative pancreas-specific complications.Background:.Pancreas-specific complications after pancreatic surgery are associated w